MMP2 and neoplasm: However, the penetration ability of Angio-DOX-DGL-GNP in vivo wasn't satisfied which may due to the sensitivity to MMP-2 degradation, but in the evaluation of anti-TNBC effect in 4T1 grafted model, Angio-DOX-DGL-GNP exhibited the highest tumor growth inhibition rate than other groups, implying that Angio-DOX-DGL-GNP accomplished our targets to some extent.