DEFA4 and adenocarcinoma: Amongst the 50 most up-regulated and the 50 most down-regulated genes in adenocarcinomas, it is worth noting that several Paneth cell-specific genes, including those that code for defensins (DEFA5, DEFA-RS2, DEFA4) [15], secretory phospholipase A2 (PLA2G2A), frizzled-5 (FZD5) and matrix metallopeptidases (MMPs), were differentially expressed.