EPDR1 and hypertensive disorder: On the other hand, genes that were seldom reported to be related with hypertension showed extremely expression changes, such as the NAT8L, OGFOD2, RBP7, 5-HTR2B, AR-β3 and EPDR1. Based on their known functions, these data may aid in the delineation of the molecular mechanisms that underlie the potential antihypertensive activities of HBMP.