On the other hand, genes that were seldom reported to be related with hypertension showed extremely expression changes, such as the NAT8L, OGFOD2, RBP7, 5-HTR2B, AR-β3 and EPDR1. Based on their known functions, these data may aid in the delineation of the molecular mechanisms that underlie the potential antihypertensive activities of HBMP. This evidence concerns the gene ASPNAT and hypertensive disorder.