Immunohistochemical analysis of patient livers with HBV (patient # 30), HCV (patient # 29, 32, 36) and non viral patients (patient # 16, 28, 50) indicates that P2X3 overexpression in HCC tumors as compared to uninvolved livers can be detected in HCC livers, irrespective of etiology (Figure 1C & Suppl. Here, P2RX3 is linked to hepatocellular carcinoma.