Furthermore, we investigated the pathological and proliferation status of these tumors by H&E and Ki67 staining, but no significant difference were detected among these groups (Supplementary Figure S2a, S2b), however, we found dramatically more Caspase3 positive staining in the tamoxifen and STF-080310 treated tumors, suggesting more apoptotic cell death of tumor cells in this group (Figure 3e, 3f). This evidence concerns the gene MKI67 and neoplasm.