Indeed, we also found an inverse correlation of EZH2 (eg. decreased expression upon EZH2 knock down and increased expression upon EZH2 overexpression) and the expression of miR-221, which facilitates EMT in bladder cancer [34] and miR-222, which is associated with poor outcome in BC patients [35, 36] (Fig. 8B, 8C). This evidence concerns the gene EZH2 and breast cancer.