The BCR-ABL1 gene fusion, a product of a chromosomal translocation involving chromosomes 9 and 22 [2, 3], encodes for a constitutively active tyrosine kinase that drives the pathogenesis of chronic myeloid leukemia (CML) [4–9]. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.