In this study, we investigated two IL-4 gene polymorphisms in patientswith PCM and control subjects from an endemic area: the dimorphic intron-3 polymorphism,which is represented by a microsatellite in which RP1 corresponds to two repetitions inthe 70-bp sequence and RP2 to three repetitions in the same sequence and a polymorphismin the promoter region, which corresponds to a C/T substitution at position -590 (Cantagrel et al. 1999). Here, IL4 is linked to paracoccidioidomycosis.