Particularly, these four molecules resulted up-regulated normalizing their concentration both on supernatant of MSCs alone (IL-8 10.6 FI, CCL4 148.6 FI, CCL11 6.7 FI and CXCL10 49.7 FI, Figure 4C) and on supernatant of CLL B cells alone (IL-8 5.8 FI, CCL4 1.8 FI, CCL11 6.9 FI and CXCL10 4411 FI, Figure 4D). This evidence concerns the gene CXCL8 and B-cell chronic lymphocytic leukemia.