ITGA4 and B-cell chronic lymphocytic leukemia: Since CD49d plays a critical role in cell adhesion and increases the ability of malignant cells to access to protective niches [35], we addressed the effect of the two kinase inhibitors on its expression on CLL B cell surface, demonstrating that the treatment with Bafetinib and Ibrutinib significantly decreases CD49d expression in co-culture with MSCs (MFI ratio 0.87±0.12 Bafetinib, p < 0.05, and 0.89±0.05 Ibrutinib, p < 0.01) (Figure 9C).