In the present study, CXCL13 and CXCR5 were up-regulated in tumor tissues, especially in poorly differentiated tumors, suggesting that both CXCL13 and CXCR5 are correlated with HCC and their up- regulation were probably the results of integrated factors in worse tumor environment. The gene discussed is CXCR5; the disease is hepatocellular carcinoma.