The frequency of CXCR5+CD45RA− cells did not differ significantly between the HCC and HC groups (Figure 1B); however, IL-21 concentration was significantly lower in the culture supernatant of sorted CXCR5+CD45RA−CD4+CD3+ and IgD+CD27−CD19+CD3− cells from HCC patients than in that from HC (Figure 1C). Here, CXCR5 is linked to hepatocellular carcinoma.