Coherently with this effect on microfilaments and with the results previously reported in other tumor cell lines [11], the western blotting analysis showed a marked decrease of the active form of the protein of focal adhesions (p-FAK), strongly involved in the migration capability of cells, in the presence of reparixin, thus confirming that also in MDA MB231-derived mammospheres, reparixin action is mediated by inhibition of the FAK/AKT pathway that is not affected by paclitaxel. The gene discussed is PTK2; the disease is neoplasm.