BIRC5 and hepatocellular carcinoma: We observed that a lethal dose of sorafenib down-regulated β-catenin, survivin, Mcl-1, and PTMA in non-cancerous Chang liver and HCC cells (Huh7, SK-Hep1, Mahlavu, and J7) (Figure 1C, note that Mcl-1 increased in Huh7 cells).