Once the primary cytogenetic subtype of MM is identified, with repeat bone marrow examinations carried out at relapse a more limited probe set is adequate, for example: 1p36.3(TP73), 1q21(CKS1B), 8q24 (3'MYC,5'MYC), 17p13.1 (p53), and 17cen (D17Z1). Here, TP53 is linked to Miyoshi myopathy.