Patients are considered to have high-risk disease if FISH studies demonstrate one of the following abnormalities: t(14;16), t(14;20), or loss of p53 gene locus (del(17p) or monosomy 17).23, 39 There is some controversy about whether there is a true adverse biological risk associated with t(14;16) MM. The gene discussed is TP53; the disease is Miyoshi myopathy.