We explored the binding of Ikaros on the promoter regions of c-MYC and MYCBP2 by qChIP and found that Ikaros significantly binds to their promoter regions in Nalm6 B-ALL and Molt4 T-ALL cells (Fig. 3C and 3D), and CEM T-ALL cells (data not show). Here, MYCBP2 is linked to acute lymphoblastic leukemia.