We also identified Ikaros binding profiling in ALL cells (15), and found that Ikaros exert its antitumor effect by regulating the expression of its gene targets (15); and CK2 inhibitors restore Ikaros function by increasing Ikaros binding to the gene targets and regulation of their expression in ALL cells [15, 16]. This evidence concerns the gene IKZF1 and acute lymphoblastic leukemia.