Ikaros dysfunction results in the upregulation of c-MYC and downregulation of MYCBP2. This is the first report shows that Ikaros dysfunction results in the increase of c-MYC and decrease of MYCBP2, as well as a negative correlation between c-MYC and MYCBP2 in ALL patients. This evidence concerns the gene IKZF1 and acute lymphoblastic leukemia.