MYC and Splenomegaly: The percentage of patients exhibiting splenomegaly, liver infiltration, and increased lactate dehydrogenase (LDH) was significantly higher in the high c-MYC expression group than in the low expression group (53.0% vs 36.1%, P = 0.039; 34.8% vs 15.5%, P = 0.006; 49.2% vs 31.2%, P = 0.033) (Supplemental Table 1, Fig. 1D).