We analyzed the correlation of Ikaros expression with that of c-MYC or MYCBP2 in the reported cohort of B-ALL or T-ALL patients [17–19], and found that Ikaros expression is negatively correlated with high c-MYC expression and low MYCBP2 expression in both B-ALL (Supplemental Fig. 5A and 5B) and T-ALL (Supplemental Fig. 6A and 6B). The gene discussed is IKZF1; the disease is acute lymphoblastic leukemia.