Furthermore, miR-3151 over-expression also led to the 58% downregulation of PIK3R2 protein, which was associated with a 75% reduction of the downstream phospho-AKT (Thr308) protein but not phospho-AKT (Ser473), showing that miR-3151 methylation/silencing accounted for constitutive PIK3R2/PI3K/AKT activation in CLL (Figure 6B). The gene discussed is PIK3R2; the disease is B-cell chronic lymphocytic leukemia.