Recently, the updated GWAS meta-analysis, which included a total of 3,100 individuals with CLL cases and 7,667 controls, identified 12 new CLL susceptibility loci, some of which harbor apoptosis-regulating tumor suppressor genes (such as BIM, NOXA) downregulated in CLL [20]. This evidence concerns the gene PMAIP1 and B-cell chronic lymphocytic leukemia.