ANXA5 and neoplasm: Overexpression of miR-3151 led to a 20% reduction of cell proliferation as measured by MTT assay (P = 0.04, Figure 4B), an addition of 12% dead cells by Trypan blue exclusion assay (P = 0.003, Figure 4C) and an addition of 10% apoptosis cells as shown by Annexin V and PI staining (P = 0.03, Figure 4D), suggesting a tumor suppressive role of miR-3151 in CLL.