The radioresistance mechanisms detected include alterations of cell cycle distribution, upregulation of PI3K/AKT signaling, higher expression of DNA repair genes, and elevated production of prosurvival and angiogenic factors (IL-6, PDGFB and SDF-1) and CXCR4 receptors important for lung cancer progression and metastasis. The gene discussed is CXCL12; the disease is lung cancer.