Our model proposes: i) potential drug targets for anti-proteasome and anti-spliceosome therapy within the same GABPA gene network, in addition to traditional adjuvant chemo- and hormonal treatment and ii) the 73-SAGPs representing a pool of co-expressed paired genes could be used for in-depth studies of fine regulatory mechanisms of tumorigenesis and tumor progression in BC (Supplementary file 1: Table S13 and Figure 9). Here, GABPA is linked to breast cancer.