To investigate the involvement of TRAP1 in tumorigenesis, breast cancer cells (MCF-7, MDA-MB-231, MDA-MB-436, MDA-MB-453 and MDA-MB-468) were transfected with non-silencing control (NC) or TRAP1-specific shRNA (shTRAP1) vectors (Figure 1B). The gene discussed is TRAP1; the disease is breast carcinoma.