We reported here that breast cancer samples express high levels of TRAP1 compared with adjacent normal breast tissues, while knockdown of TRAP1 attenuated the tumorigenicity of both MDA-MB-231 and MCF-7 cells in nude mice, suggesting the requirement of TRAP1 in breast cancer tumorigenesis and progression, which was consistent with previous findings [25]. This evidence concerns the gene TRAP1 and breast carcinoma.