ADIPOQ and obesity due to melanocortin 4 receptor deficiency: Engeli et al. [34] found that the inverse relationships between insulin resistance in non-diabetic postmenopausal women and adiponectin mRNA expression and the plasma concentration of the adipokine were independent of the BMI and percent body fat; moreover, the observed inverse correlation between plasma CRP and adiponectin concentrations persisted after adjustment for obesity-related variables.