Our findings that abdominal SAT is a predominant site of at least some of pro-inflammatory cytokine synthesis, and that the correlation between IL-6 serum and SAT concentrations is observed only in the obese, support the view that increased amount of SAT in the obese might also contribute to metaflammation observed in obesity. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.