IL6 and obesity due to melanocortin 4 receptor deficiency: On the other hand, in our study, obesity was associated with increased synthesis of IL-6 in VAT, which is in agreement with the results of studies assessing IL-6 concentrations at the mRNA level, including micro-array studies [44,45], as well as the results of in vitro experiments showing that adipocytes isolated from VAT of obese individuals release more IL-6 than those from normal-weight subjects [34,35].