In southeast Hungary, between 2001 and 2006, 9.6% patients with an average age of 53 years (age range: 16–85 years), showing acute hepatitis symptoms, were positive for anti-HEV IgM (116/1203), and 24.5% of them were also HEV-RNA positive [102]. The gene discussed is CD40LG; the disease is Acute hepatitis.