Accordingly, the expression of TNF-α is tightly regulated during an immune response to an infection or during autoimmune diseases, and there are many drugs targeting TNF-α and its receptors, for example, infliximab, certolizumab, and etanercept, which are designed for the treatment of inflammatory diseases such as rheumatoid arthritis [17–18]. This evidence concerns the gene TNF and rheumatoid arthritis.