Roccaro et al. [20] identified that miR-15a/16-1 regulated the proliferation of MM cells in vitro and in vivo by inhibiting AKT serine/threonine protein kinase (AKT3), ribosomal-protein-S6, MAP-kinases, and NF-kB activator MAP3KIP3. Here, RPS6 is linked to Miyoshi myopathy.