The expression of Kras (5-fold), Galectin-3 (5-fold), EGFR (3.5-fold), TGFβ1 (3.5-fold), cMyc (2.8-fold), Fut8 (2.5-fold), and Bcl2 (2-fold) were significantly upregulated, while the expression of PTEN was significantly downregulated in KC animals compared to controls (Figure 2G). This evidence concerns the gene KRAS and keratoconus.