CALCA and pancreatic ductal adenocarcinoma: Our previous study using the KrasG12D;Pdx1-Cre (KC/floxed KrasG12D) PC mouse model showed the presence of pancreatic intraepithelial neoplasia (PanIN) lesions as early as 10 weeks of age; these lesions progressed to pancreatic ductal adenocarcinoma (PDAC) and metastasized to the liver, lungs, and intestines by 50 weeks of age [26].