Further, Kent et al. (2009) reported downregulation of miRNA-200 family members, including miRNA-141, in PC cell lines [48] and observed a positive correlation between the expression of miR-200 family members and E-cadherin expression, as well as a negative correlation with the zinc-finger E-box-binding homeobox 1 (ZEB1) [48, 49]. This evidence concerns the gene CDH1 and pachyonychia congenita.