In addition, three known SNP markers, rs55999272 in the CRYGEP gene, rs2276109 in MMP12, and 18 bp deletion within the promoter of CETP, are associated with a reduced risk of Coppock-like cataract [100], asthma [101], systemic sclerosis [102], psoriasis [103], and atherosclerosis [104, 105] due to the SNP-caused damage to the TBP-binding sites of the promoters of these genes. The gene discussed is MMP12; the disease is systemic sclerosis.