2005), it is feasible to suggest that hyperglycemia also affects the ventral horn microenvironment. Such changes include significant loss of inhibitory terminals in apposition to motoneuron cell bodies, as seen by synaptophysin immunolabeling and TEM. Our work is consistent with previous data, in which reduction in synaptophysin immunolabeling was depicted 20 weeks after the onset of the disease (Jiang et al. 2010). The gene discussed is SYP; the disease is Hyperglycemia.