The presence of BPH was positively associated with LH (β = 0.231; P = 0.001), free testosterone (β = 0.257; P = 0.009), and insulin (β = 0.148; P = 0.025) and negatively with SHBG (β = −0.266; P = 0.001), estradiol (β = −0.227; P = 0.003), and DHEA-S (β = −0.162; P = 0.030). The gene discussed is PLOD1; the disease is benign prostatic hyperplasia.