F5 and Rare hereditary thrombophilia: However, it has been associated with some risk factors for thrombophilia such as myeloproliferative disease [12], coagulation factor deficiency, factor V Leiden [13] and prothrombin gene mutation [14], portal hypertension, post-splenectomy, malignancy, intra-abdominal infection or inflammation [15], pregnancy, oral contraceptive use, and so on.