TP53 and neoplasm: Our results suggested that DMSO induce apoptosis dominantly in a wide variety of tumor cells through targeting many of the cisplatin apoptotic protein as overexpression of P53 [25], P21 [26], Bcl-2 and Bcl2/bax ratio [27] This will able DMSO to potentiate the cisplatin induced-apoptosis and lead to more killing effect.