These data complement recent work linking TF binding to enhancers and tissue‐specific hypomethylation (Stadler et al, 2011; Hon et al, 2013; Xie et al, 2013; Ziller et al, 2013) and suggest a theoretic model in which the incomplete epigenetic remodeling in PD DAn might be related to the downregulation of a network of key TFs whose deficiency could prevent their binding sites to become demethylated during the differentiation from iPSCs to DAn. This evidence concerns the gene TF and Parkinson disease.