MAPK8 and lip and oral cavity carcinoma: In agreement with these results, Chen et al. found that Bay 11-7082 and also SP600125, an inhibitor of JNK (Table 1), greatly reduced the amount of apoptotic human Ca9-22 oral cancer cells following ALA-PDT, suggesting that NF-κB and JNK jointly regulate apoptotic signaling following PDT [275].