Besides its role in tumor (re)growth, STAT3 also prompts the immune system by assisting in the production of a wide array of proinflammatory cytokines and chemokines that includes, but is not limited to, CCL2, CXCL2, IL-1β, IL-1α, TNF-α, and IFNγ (the role of STAT3 in conjunction with NF-κB is comprehensively reviewed in [231]). This evidence concerns the gene NFKB1 and neoplasm.