On the one hand, the downstream targets of NF-κB are instrumental for tumor cell survival following PDT, such as COX-2 and survivin, of which the inhibition results in increased tumor cell death and better tumor control (sections 3.2.4.2 Inhibition of COX-2 and 3.2.4.3 Inhibition of survivin). The gene discussed is BIRC5; the disease is neoplasm.