Approximately 30–40 % of cases of DLBCL are characterized by recurrent chromosomal translocations involving BCL6/3q27, BCL2/18q21.3, and MYC/8q24.4 in about 30, 20, and 10 % of DLBCL cases, respectively. This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.