For example, a recent review stated that although CSCs can be purified from CD133+ subpopulations in lung, colon, liver, pancreas and skin cancers, CD133 appears to be a general marker for the apical or apicolateral membrane and cannot be used alone to isolate stem cells rich in glandular epithelia, such as from the stomach or the breast [29]. Here, PROM1 is linked to skin neoplasm.