GSK3B and breast cancer: In summary, Amiodarone was shown to induce VcanV2, the mammalian ortholog gene of zebrafish s-vcanb, resulting in the inhibition of EGFR/ERK/GSK3β/Snail signaling and, consequently, the increase of E-cadherin, leading to the suppression of migration, invasion, and metastatic capabilities of breast cancer cells.