EGFR signaling regulates cell motility through activation of EGFR's intrinsic kinases, leading to the activation of several downstream intracellular signaling pathways, including rat sarcoma–MAPK kinase (MEK), extracellular-related kinase (ERK), phosphoinositide 3-kinase (PI3K) and AKT pathways. The gene discussed is EGFR; the disease is sarcoma.