To determine the contribution of bone marrow-derived LMP7 to the prevention of obesity, we generated 3 types of bone marrow-transferred chimeric (BMT) mice (WT → WT, LMP7−/− → WT, WT → LMP7−/−) and evaluated the HFD-induced obesity. This evidence concerns the gene PSMB8 and obesity due to melanocortin 4 receptor deficiency.