In order to further test our hypothesis that activation of PI3K/AKT by absent NDRG4 expression might confer proliferative and progressive ability to colorectal cancer cells under excess energy balance status, which would impact the prognostic value of obesity, we next evaluated the association of obesity with overall survival according to NDRG4 level. This evidence concerns the gene PIK3CA and obesity due to melanocortin 4 receptor deficiency.