However, we found that NDRG2 and NDRG4 mRNA expression was both decreased in colorectal cancer and adversely associated with clinical outcome within the same study cohort, indicating a tumor suppressive role of NDRG4 in colorectal cancer, which was similar to the role of NDRG2 in colorectal cancer [44]. Here, NDRG2 is linked to colorectal cancer.