NDRG4 and obesity due to melanocortin 4 receptor deficiency: Interestingly, we found that, among tumors with NDRG4 reduced expression, obesity was associated with significantly worse overall survival (Figure 1B, log-rank test: P = 0.017), with unadjusted HR to be 1.65 (95% CI: 1.09–2.51 P = 0.018).