In a word, our study demonstrated that the impact of age on OS of lobular breast cancer in ER+PR- and ER-PR+ subtypes were more likely to be similar with that in ER-PR- subtype rather than ER+PR+ subgroup, and young age was not a predictor for worse overall survival in ER+PR-, ER-PR+ or ER-PR- lobular breast cancer. This evidence concerns the gene ESR1 and Hereditary breast cancer.