Rossille et al. [18] did not find an association between plasma sPD-L1 levels and tumor PD-L1 expression in DLBCL patients, suggesting that non-malignant cells in the tumor microenvironment can produce sPD-L1 in response to pro-inflammatory cytokines [23, 24]. The gene discussed is SPDL1; the disease is diffuse large B-cell lymphoma.