At 5q23.3, only two genes were detected (HINT1 and RAPGEF6) in microarray data and HINT1 was significantly down-regulated in tumor tissues; and in TCGA database, three nearby genes (LYRM7, CDC42SE2, and FNIP1) were significantly down-regulated in tumor tissues but CHSY3 was significantly up-regulated. This evidence concerns the gene RAPGEF6 and neoplasm.