Moreover, the IL-6/STAT3/JAK2 pathway is involved in the maintenance of stem cell–like cancer cells [36] because CD44+CD24+ and CD44+CD24− breast cancer cells have high phospho-STAT3 via their expression of genes such as IL6, PTGIS, and HAS1, which activate an autocrine loop [8]. The gene discussed is PTGIS; the disease is breast cancer.