The correlation between high SPC24 expression and clinicopathologic variables was evaluated, higher SPC24 expression was positively associated with worse clinicopathologic characteristics including AFP >200 ng/mL, tumor size >5 cm, multiple tumor nodules, and high BCLC stage (B-C), all of which actually linked with the poorer prognosis in HCC, suggesting that SPC24 might be closely associated with the progression, invasion and metastasis of HCC. The gene discussed is SPC24; the disease is hepatocellular carcinoma.