In addition, high SPC24 expression (p < 0.001), AFP > 200 ng/mL (p = 0.029), size of tumor >5 cm (p < 0.001), multiple tumor number (p < 0.001), B-C of BCLC stage (p < 0.001), the presence of PVTT (p < 0.001), distant metastasis (p = 0.043), and recurrence (p < 0.001) were negative prognostic factors for OS in patients with HCC after resection (Table 2). This evidence concerns the gene SPC24 and hepatocellular carcinoma.