NUF2 and cancer: Kinetochore proteins were involved in cancers including HCC, for instance, the expression of Nuf2 was significantly enhanced in human HCC tissues compared with the corresponding adjacent normal tissues, lentivirus-mediated silencing of Nuf2 in HepG2 cells markedly suppressed short-term proliferation and long-term colony formation capacity, induced cell cycle arrest, and triggered cell apoptosis [33].