In Kaneko's report, mRNA of CDCA1, KNTC2, SPC24 and SPC25 was overexpressed in colorectal and gastric cancers compared with the corresponding normal mucosa, siRNA-mediated knockdown of either CDCA1 or KNTC2 significantly suppressed cell growth and induced HCC cell apoptosis [34]. This evidence concerns the gene NDC80 and hepatocellular carcinoma.