High SPC24 expression (HR, 2.122; 95% CI, 1.335–3.374; p = 0.001), PVTT (HR, 1.872; 95% CI, 1.185–2.957; p = 0.007), size of tumor > 5 cm (HR, 2.892; 95% CI, 1.642–5.094; p < 0.001) were independent prognostic factors for DFS in HCC patients, and high SPC24 expression (HR, 2.510; 95% CI, 1.554–4.055; p < 0.001), PVTT (HR, 1.666; 95% CI, 1.053–2.636; p = 0.029), size of tumor >5 cm (HR, 2.431; 95% CI, 1.369–4.317; p = 0.002), and recurrence (HR, 2.694; 95% CI, 1.618–4.486; p < 0.001) were independent prognostic markers for OS (Table 3). Here, SPC24 is linked to neoplasm.