The data showed that SPC24 mRNA level was significantly higher in the group with AFP >200 ng/mL than that ≤200 ng/mL (χ2 = 4.046, p = 0.044), and it is higher in the group with diameter of tumor > 5 cm than that ≤5 cm (χ2 = 4.696, p = 0.030), and this tendency was also found in the group with multiple tumor nodules than that with a single tumor (χ2 = 5.461, p = 0.019). The gene discussed is SPC24; the disease is neoplasm.