GMFB and central nervous system cancer: However, multivariate survival analysis verified that GMF-β expression in endothelia was the only independent predictor of both PFS (P < 0.0001, HR = 1.244, 95% CI = 1.136–1.363) and OS (P < 0.0001, HR = 1.236, 95% CI = 1.126–1.358) in glioma patients (Table 1).