PITX1 and colitis: B. fragilis is known to induce signal transducer and activator of transcription 3 and Th17-dependent pathway in colitis-associated CRC (see Supplementary Data 8 for detection of bft genes from enterotoxigenic B. fragilis)37 whereas the abundance of Granulicatella adiacens in saliva is associated with chronic pancreatitis and pancreatic cancer39.