In bone marrow stromal cells, LPS induces WNT-5A where it regulates expression of a plethora of proinflammatory cytokines in a MAPK- and NFκB-dependent signaling and promotes chemotactic migration of monocytes and T cell indicating a possible role in pathophysiology of rheumatoid arthritis [30]. The gene discussed is WNT5A; the disease is rheumatoid arthritis.