In a breast cancer cell line MDA-MB-231 which expresses very low endogenous WNT-5A, stimulation with WNT-5A activated a DVL2- and Daam1-dependent RhoA signaling inducing cell migration [110], whereas in another breast cancer cell line with high endogenous WNT-5A levels (MCF-7), WNT-5A can promote cell migration via a DVL2-Rab35-Rac1-dependent and RhoA-independent signaling [109]. Here, DVL2 is linked to breast cancer.