These changes decrease FKN affinity (McDermott et al., 2003), and several studies support a role for CX3CR1 in age-related macular degeneration (Craner et al., 2003; Tuo et al., 2004; Chan et al., 2005; Brion et al., 2011; Schaumberg et al., 2014), autoimmune uveitis (Dagkalis et al., 2009), and neurodegenerative models of Alzheimer’s disease and Parkinson’s disease. This evidence concerns the gene CX3CR1 and Parkinson disease.