To examine whether 122-Exo mediated-miR-122 communication can alter the expression of miR-122 target genes, such as cyclin G1 (CCNG1), a disintegrin and metalloprotease 10 (ADAM10), and insulin-like growth factor receptor 1 (IGF1R) in hepatoma cells [13, 14], HepG2 cells were exposed to 122-Exo or 67-Exo for 24 h. This evidence concerns the gene IGF1R and hepatocellular carcinoma.