SPP1 and myocarditis: As the G allele is expected to reduce SPP1 expression[28], this trend would be in the direction suggested by over-expression experiments of SPP1 in the murine myocardium, causing myocarditis and myocardial dilation[23]; but in the opposite direction compared to described effects of SPP1 rs28357094 on skeletal muscle (greater weakness associated with the G allele)[19,24,25,29,39].