There was a trend towards later onset of DCM in patients carrying the LTBP4 rs10880 T/T vs. C/C-C/T genotype (median 29.5 vs.19.0 years, n = 31 and 137 respectively, log-rank p = 0.13) (Fig 2B). This evidence concerns the gene LTBP4 and familial dilated cardiomyopathy.