In addition, the xenograft tumor appearance time (days) were significantly decreased in CUDR overexpression, CUDR overexpression plus CyclinD1 overexpression and CUDR overexpression plus PTEN knockdown groups compared to control respectively (12.3 ± 3.1 days, 7.9 ± 1.4 days, 9.7 ± 2.5 days vs 0 P < 0.01 respectively). Here, PTEN is linked to neoplasm.