In this regard, mice pretreated with 3-epiCA and MA exhibited 4.33 and 3.73 papillomas per mouse, respectively giving a 59% and 65% inhibition in tumor multiplicity (p < 0.05; Mann-Whitney U test compared to the TPA only group and the UA + TPA group, respectively) (see again Figure 1A and Table 1). The gene discussed is PLAT; the disease is papilloma.