CD8A and neoplasm: To allow the epitope-specific analysis of a well-defined CD8+ T-cell response against a tumor antigen in WAP-T mice, we inserted the coding sequence (a 33 bp oligomer) for the MHC class I H-2d-restricted T-cell epitope NP118–126 of LCMV into a transformation-irrelevant C-terminal region of T-Ag, to obtain WAP-TNP mice (Fig. 1A, a detailed description of the WAP-T/WAP-TNP mice used in this study is given in Materials and Methods).